Acetylcholinesterase Inhibition and Information Processing in the Auditory Cortex

摘要

Foundational characterization of cholinergic alteration of information processing was accomplished in the auditory cortex of unanesthetized cat by micropressure and iontophoresis during controlled pure tone stimulation. Discharges of single neurons for both single tones and frequency tuning functions were altered by muscarinic agonists, antagonists, and cholinesterase blockers in highly selective and specific ways. Agonist effects were systematically shifted by agonist and anticholinesterases, with soman tuning shifts shifts being uniquely permanent. Keywords: Acetylcholine; Atropine; Central nervous; system; Auditory cortex; Neurons; Muscarinic; Tuning curves; Scopolamine; Brain; Acetyl beta methacholine. (AW)