Neurophysiological Research Supporting the Investigation of Adaptive Network Architectures

摘要

Research demonstrated that rates of learning of a conditioned eyeblink response in cats could be significantly accelerated by adding electrical stimulation of the hypothalamic region of the brain at the appropriate time interval in relation to the conditioning stimuli. This learning model was extended to obtain rapid conditioning of single cortical neurons. Changes in currents in the conditioned cells were detected using the single electrode voltage clamp technique. Long lasting increases in input resistance and excitability similar to those produced by acetylcholine were found after applications of cyclic GMP-dependent protein kinase and cGMP. Keywords: Conditioning stimuli; Conditioning cortical neurons; Acetylcholine. (aw/mjm