Decision Tree Network for the Identification of Nerve Agent Treatments: Reactivators

摘要

The Reactivator Decision Tree Network described is a screening procedure designed to rapidly identify potential replacements for the presently fielded acetylcholinesterase reactivator pralidoxime chloride (2-PAM). Selection of a replacement will be based on three factors: (1) improved efficacy against a broad spectrum of organophosphorus agents; (2) improved ability to alleviate agent-induced incapacitation; and (3) minimal side effects at therapeutic doses. This series of screening tests is designed only to select the most promising candidates for advanced testing and is intended to be followed by more complete safety and efficacy evaluations as a part of predevelopment advanced testing.