Dermal Sensitization Potential of a Schistosome Topical Antipenetrant Lotion in Guinea Pigs

摘要

A schistosome topical antipenetrant lotion, containing 1% niclosamide, was tested for its potential to produce dermal sensitization. The Guinea Pig Maximization Test was used to evaluate dermal sensitization potential. Grade II (mild) dermal sensitization to the lotion was obtained in this study. These results suggest that there is probable risk that the schistosome topical antipenetrant lotion will induce contact sensitivity in humans.