Epidemiological Survey for Incidence of Shigellosis and Hepatitis to Evaluate Potential Field Test Sites for Vaccine Trials. Part 1. Shigellosis

摘要

The aim of this study was to determine the incidence of shigellosis in selected units in the IDF and to evaluate the associa-homologous Shigella and the occurrence of disease. In this study, soldiers in five units were followed prospectively for the occurrence of diarrheal disease. Blood samples were taken at the beginning and end of the study period. In four of the units, both blood and stool samples were taken from cases of diarrhea at the time of the event. Serologic response was determined by enzyme linked immunosorbent assay (ELISA). Epidemic and sporadic morbidity due to Shigella organisms was identified using bacteriological and serological diagnostic methods. The presence or absence of specific antibodies against Shigella at the onset of disease were compared in cases and healthy controls from the same units. The presence of specific antibodies of the IgG class was a significant marker of protection against shigellosis due to homologous organisms. Keywords: Diarrhea; Dysentery; Epidemiology; Serology; Immunology; Bacteriology; Shigella vaccines; RIA; Hepatitis A. (kt)