Effects of Ethiofos (WR-2721) and Radiation on Monkey Visual Discrimination Performance

摘要

WR-2721 (ethiofos) is a promising protector against radiation-induced lethality and may be useful in cancer radiotherapy (Davidson et al., 1980). However, ethiofos also produces nausea, vomiting, diarrhea, and hypotension, which implies severe behavioral consequences (Bogo et al., 1985). We studied the effects of ethiofos on behavior in monkeys and its ability to mitigate early transient incapacitation (ETI). ETI is the abrupt cessation of performance (for at least 1/min) following rapidly delivered, high doses of radiation and usually occurs 5-10 min after irradiation and lasts for 1-5 min (Bogo, 1988a). Keywords: Reprints.