Development and Evaluation of Adeno-HTLV-III Hybrid Virus and Non-Cytopathic HTLV-III Mutant for Vaccine Use

摘要

Acquired immunodeficiency disease syndrome (AIDS ) was initially recognized as a separate disease in 1981. Results from research groups in France and the United States determined that a previously unknown virus called HIV is the primary aetiological agent of AIDS. Two HIV vaccines, a recombinant Adeno-HIV hybrid virus and a recombinant vaccinia HIV will be tested. The recombinant Adeo-HIV virus is being developed as part of this proposal. We will focus on whether generation and cloning of HIV specific killer T cells could be used to protect humans from AIDS.