Differential Migration of Lymphoblasts and Small Lymphocytes Induced by Mitogens in Culture: Characteristics of Lymphoid Cells. (Reannouncement with New Availability Information).

摘要

Lymphoid cells from peripheral lymph nodes, spleen, and gut-associated lymphoid tissues (mesenteric lymph nodes and Peyer's patches) of the mouse were stimulated by concanavalin A and bacterial lipopolysaccharide in culture; their migration in the mouse was studied. Lymphoblasts and small-medium lymphocytes from the cultures, irrespective of their tissue origins, showed a differential migration when they were passively transferred into syngeneic, immunoglobulin-allotype congeneic or allogeneic recipients. Large lymphoblasts, at last S and G2 + M phases and without MEL-14 reactive determinants, migrated preferentially to the gut. In contrast, small and medium lymphocytes, at Go/Gl and early S phases and with MEL-14 reaction determinants, migrated preferentially to the spleen and liver.