Biological Changes in the Regenerating and Intact Rodent Liver Following Exposure of the Organ to Lasers. (Reannouncement with New Availability Information).

摘要

Young adult males of the Holtzman and Charles River strains were partially hepatectomized by the Higgins and Anderson procedure, two-thirds of the organ being extirpated. The liver remnant of such animals as well as definite areas of sham operated rats were directly exposed to lasers (fiber). The respective controls were manipulated but not irradiated. They were caged individually and administered Purina rat pellets and water ad lib over a period of 10 days, at which time, they were exsanguinated and the entire liver removed. The more widely studied Nd-YAG laser produced lesions at the irradiated sites, severity being dependent on the power and was accompanied by surface temperature rises. With Nd-YAG at 3.0-8.0 W, carbonization at the surface ranged 4-11 mm in dia with surrounding halo or tailing necrotic zone and thickness, up to 4 mm; several livers were 'burnt' at 5.0-8.0 W laser application and others presented yellow-brown necrotic larger spheres containing carbonized debris.