Investigations of Tissue-Level Mechanisms of Primary Blast Injury Through Modeling, Simulation, Neuroimaging and Neuropathological Studies.

摘要

Traumatic brain injury (TBI) to U.S. soldiers has become one of the most taxing consequences of IED attacks in OEF/OIF. This project has focused on investigations of traumatic injury to the brain caused by the primary effects of blast waves. The project combines clinical, experimental and modeling studies aimed at: (i) elucidating the cell and tissue-level mechanisms of injury produced by the effect of the blast wave, (ii) deriving associated blast injury criteria (metrics and thresholds), (iii) helping to identify and treat returnees suffering from TBI, and (iv) developing blast protection strategies for TBI mitigation.