Serum Immunoglobulin and Complement Responses to 6% Dextran-70/7.5% Hypertonic Saline Solution in Dogs and Pigs.

摘要

HSD is a resuscitative fluid which has shown great promise in experimental trials. However, clinical use of modern dextran solutions has been limited by concerns of anaphylactoid reactions. To assess the short term immunogenic response to HSD, analyses for total immunoglobulins, IgG, IgM, and C3 complement were performed on sera of hemorrhaged and euvolemic pigs receiving HSD (4 ml/kg) and euvolemic dogs infused with either 6% Dextran-70 in normal saline (Macrodex) or HSD 20 ml/kg). In swine, serum IgG, IgM, and total immunoglobulin titers were unchanged in response to hemorrhage and/or HSD infusion over the 120 hr experimental period. Total immunoglobulin titers were essentially unchanged in unhemorrhaged, HSD infused pigs over a three week period. Keywords: Dextran, Hypertonic saline, Immunoglobulins, Complement, Anaphylactoid reactions, Hemorrhage, Immunoelectrophoresis, Dogs, Pigs.