Optimizing Segmental Bone Regeneration Using Functionally Graded Scaffolds.

摘要

The overall objective of this project is to develop a clinically applicable load-bearing, anti-infective, and osteoinductive functionally graded scaffolds (FGS) as synthetic long bone grafts to treat combat-relevant segmental long bone fractures. Our central hypothesis is that a load bearing, anti-infective, and osteoinductive FGS as bone substitutes can be achieved by manipulating the synthetic graft structure and chemical composition to mimic natural long bones, and by incorporating antibiotics and bone formation growth factors. Manipulation of the graft structure and composition will allow for temporally and spatially controlled release of these antibiotics and growth factors. Together with the structural support provided by the graft that will allow for earlier weight bearing, we can accelerate bone regeneration and reduce the incidence of infection in long bone defects caused by combat- relevant extremity injuries. If the prototype of the synthetic long bone grafts proves successful, the product will provide a significant benefit to the lives of individuals who have sustained combat-relevant orthopedic injuries. Injured soldiers could fully restore the function of their legs in a much shorter period of time and eventually regenerate the long bone.