Cardiopulmonary Effects of Acute Stressful Exercise at Altitude of Individuals with Sickle Cell Trait (SCT).

摘要

A spectrum of exercise induced complications including sudden unexpected death has been reported in individuals with sickle cell trait (SCT). The etiology of these results and the role that sickling may play remain uncertain. We have previously demonstrated comparable human performance to short periods of exhaustive exercise without discernible clinical differences between SCT and controls at 127 meters, at stimulated 2300 meters and after seven weeks of army basic training (see appendix). Also we did not observe significant increases in sickling in peripheral venous blood with exercise nor with acute exposure to environmental hypoxia equivalent to 3000 meters. Keywords: Sickle cell trait, Hemoglobin AS, Exercise in sickle cell trait, Hypoxia and sickle cell trait, RA 3, Cardiopulmonary effects, SCT, Stress physiology. (jg)