Effects of TRH (Thyrotropin-Releasing Hormone) in Circulatory Shock and Central Nervous System Ischemia.

摘要

Thyrotropin-releasing hormone (TRH) is an enormously versatile substance that has many pharmacological effects beyond its established hypophysiotrophic actions. Experimental evidence has accrued to indicate that TRH used as a drug may be a treatment of choice for anaphylactic shock, spinal injury, and amyotrophic lateral sclerosis and be used as an analeptic agent to reverse the effects of anesthetics. The potential use of TRH in the treatment of septic shock hemorrhagic shock, and stroke remains to be further established. Nonetheless, several potent analogues of TRH are available, and each may offer a different pharmacological spectrum of action that should be evaluated in these clinically relevent disorders. Because TRH is enormously safe at large doses in animals and man future clinical trial with TRH and its analogues may provide additional support for the further exploitation of these substances in clinical medicine. Keywords: Endotoxic Shock, Ischemia, Central nervous system, Injury; Spinal trauma; Spinal transection, Spinal cord; Pathophysiology. Reprints. (AW)