Molecular Interactions on the Cell Surface Revealed by Electrophoresis.

摘要

The intriguing finding of Jaffe and Stern and others (Jaffe and Stern, 1979) that strong ionic currents can be detected in the vicinity of developing embryos and the observation the migratory and/or growth patterns of cells separated from explanted embryonic tissue (Jaffe and Poo, 1979) can be controlled by externally applied electric fields both support the notion that the coupling of extracellular electrical currents to cellular function is physiologically important. The search for an understanding of the mechanisms and sites of coupling of these electric fields to living cells has to led to a new probe of both cellular architecture and function. We report here on some of our work on one physical interaction induced by exogenous electric fields: the redistribution of cell surface membrane components by surface electrophoresis. Reprints. (jes)