Temperature Regulation Following Systemic Anticholinergic or Anticholinesterase Therapy.

摘要

The effect of systemic atropine (ATR, 2 mg, im) or pyridostigmine (PYR, 30 mg, oral) at rest and during moderate seated cycle exercise was evaluated in two separate protocols at an ambient temperature of 30 C. Esophageal (Tes) and mean weighted skin temperatures were measured continuously, as was forearm sweating rate, forearm blood flow (FBF, venous occlusion plethesmography) and cutaneous perfusion (SkBF, laser doppler velociometry). Whole body sweating decreased 55% (P<0.05) in ATR, while heart rate increased 30 bpm (P<0.05). ATR increased the slope (central thermosensitivity) of FBF: Tes 90% (P<0.05) compared to control. The Tes for sweating onset was increased 0.3 C (P<0.05) after ATR. Keywords: Skin blood flow. (aw)