World Conference on Pre-Erythrocytic Stage Malaria Vaccine Development: Current Status and Future Prospects. Held in Bethesda, Maryland on April 12-15, 1989.

摘要

Contents: Protective immunity to Plasmodium falciparum and Plasmodium vivax induced by irradiated sporozoites: University of Maryland studies, 1971-1975; Human immunization with irradiated sporozoites; The conformational restriction of synthetic peptide vaccines for malaria; Subunit vaccine designed to induced protective antibodies against the circumsprozoite (CS) protein of Plasmodium berghei; Subunit vaccine induced polyclonal antibodies compared with irradiates sporozoite induced monoclonal antibodies in protein against Plasmodium yoelii; Induction of protective antibodies against Plasmodium berghei sporozoite by different sub-unit vaccines; Clinical trials of sporozoite vaccines at the University of Maryland; Clinical trials with sporozoite vaccines; Testing of Plasmodium vivax CS proteins in Saimiri monkeys; Anti-sporozoite antibodies and protection; This study of exo-erythrocyticstages of malaria parasites in vitro; T Cell immunity to pre-erythrocyticmalaria: lysis or lymphokines; Immunogenicity of the circumsporozoite protein of Plasmodium falciparum. A widely recognized malaria T-cell epitope; The role of T cells in immune response against Plasmodium berghei circumsporozoite protein. Cellular and humoral immune responses to a recombinant Plasmodium falciparum CS protein in sporozoite-immunized rodent hosts and human volunteers;A T cell epitope recognized by CD8+ cytotoxic T cells on the Plasmodium yoelii CS protein; T Cell proliferative responses to the Plasmodium falciparum CS protein in humans after immunization with a subunit vaccine and natural exposure to malaria.