Determination of the Toxicity of Cyclotriphosphazene Hydraulic Fluid by 21-Day Repeated Inhalation and Dermal Exposure.

摘要

This study was designed to evaluate the toxic effects associated with repeated or continuous exposure to CTP by both the dermal and inhalation routes. Rats were exposed for three weeks to air alone, 0.25, 0.50 and 1.00 mg CTP/L. No deaths or signs of toxic stress occurred during the exposure period. A treatment-related depression in mean weight gain, increases in numbers of pulmonary alveolar macrophages and renal hyaline droplets was noted in both sexes. Rabbits were treated dermally for three weeks with mineral oil, or 0.25, and 1.00 g CTP/Kg. No toxic effects were noted in either sex of rabbits. Keywords: CTP; Rat; Rabbits; Inhalation toxicity; Dermal toxicity; Hydraulic fluids. (kt)