Primary Dermal Irritation Potential of Ball Powder (Trade Name) in Rabbits

摘要

The primary dermal irritation potential of Ball Powder (Trademark) was determined in 4 male and 4 female New Zealand White rabbits by using a modified Draize method. Two Ball Powder (Trademark) skin application sites were evaluated on each animal following a 4-hour application to closely clipped skin. Very slight erythema was observed in 1 rabbit at 1 hour after wrap removal and in 2 rabbits at 24 hours after wrap removal. All rabbits had returned to normal by 48 hours after dosing. Neither edma nor any other recognizable skin reaction was detected at any time during the 14-day observation period. Ball Powder was classified as a non-irritant under conditions of this study. Keywords: Nitroguanidine; Triple base propellants; Primary dermal irritation; Rabbits, Mammalian toxicology; Propellants. (KT)