Postirradiation Glucan Administration Enhances the Radioprotective Effects of WR-2721

摘要

Based on murine survival studies, endogeneous hemopoietic spleen colony formation (E-CFU), and recovery of bone marrow and splenic granulocyte-macrophage colony-forming cells(GM-CFC), it was demonstrated that the postirradiation administration of glucan, an immunomodulator and hemopoietic stimulant, enhances the radioprotective effects of WR-2721. These effects appeared to depend on the sequential cell protection mediated by WR-2721 and hemopoietic repopulation mediated by glucan. Keywords: Radioprotective agents; Reprints. (KT)