Subjective Reactions to Atropine/2-PAM Chloride and Heat While in Battle Dress Uniform and in Chemical Protective Clothing

摘要

Subjective reactions and symptomatology were assessed during continued exposure to combinations of atropine (2 mg) and 2-PAM chloride (600 mg), heat/humidity (95 F/60%RH), and wearing either the US Army battle dress uniform (BDU) or impermeable chemical protective clothing (MOPP-IV). Reported symptoms were due primarily to heat rather than to drug, but some visual and somesthetic reactions typical of atropine were also noted. Elevated heat stress caused by wearing MOPP-IV at 95 F/60% RH significantly increased the frequency and severity of reported symptoms, compared to a parallel study under equivalent heat conditions but while wearing only BDU's. In the heat condition, subjects were able to complete all six hours of testing when wearing BDU's, but only lasted two hours in MOPP-IV. Claustrophobic reactions due to encapsulation in MOPP-IV reported in other studies were not observed. Keywords: Pralidoxime, Mood. (AW)