Antigen Markers for Clinical Manifestation and Prevention of HTLV-III/LAV Infection.

摘要

During this year's research we have found that the vpr gene product of HIV 1 is localized in the virion and that the C terminal portion of the gene is critical for its expression. We also found that the vpr open reading frame of SIV encodes a virion-associated 11 kd protein. The protein reacts with sera from infected macaques and appears to be dispensable for virus replication. In work with HIV 1 gp 120 we found that antibodies that are cross-reactive for HIV 1 and HIV 2 gp 120 are correlated with better clinical outcome. In addition, we also located a potential CD4 binding domain on the N-terminal conserved region of HIV 1 gp 120, suggesting that binding may occur through discontinuous domains.