Polymeric Catalysts With Enzyme-Like Properties.

摘要

Enzymes are acknowledged to represent the highest expression of chemical catalysis. Duplication of enzymic catalysis in synthetic materials has been pursued by many investigators for several decades. The high levels of substrate selectivity and catalytic efficiency afforded by enzymes offer advantages of immense proportions for chemical synthesis, degradation and detection. Our work is based specifically on an interest in the design, synthesis and evaluation of synthetic polymers which emulate enzymes when serving as catalysts for transacylation reactions. In recent studies polymer-supported nucleophilic catalytic sites have exhibited remarkable selectivity and/or efficiency in promoting reactions of derivatives of carboxylic and phosphoric acids.