Bioreactivity: Studies on a Simple Brain Stem Reflex in Behaving Animals.

摘要

A major problem in attempting to understand complex physiological processes, such as brain neuromodulation, or complex behavioral processes, such as arousal, is finding a simple system that will permit such analyses. The brain stem masseteric (jaw closure) reflex in cats is such a system. It is simple, containing only one synapse in brain, and receives dense inputs from two neurochemical systems important in neuromodulation and arousal. Initial pharmacologic studies showed that locally applied norepinephrine facilitated the reflex response. More importantly, physiologic conditions, known to activate the brain norepinephrine system, also facilitated the response. This latter finding was shown to be causal, rather than correlative, by a study which found that the facilitation could be blocked by prior destruction of the norepinephrine input specifically to the reflex circuitry. These data represent the first definitive example of an activational effect in an intact and behaving organisms being attributable to a particular central neurotransmitter acting at a specific brain site. (sdw)