Pyridostigmine and Warm Water Diving Protocol 90-05: 2. Thermal Balance.

摘要

A study was conducted to evaluate whether pretreatment with pyridostigmine affected the thermal balance of divers in warm water conditions. Ten U.S. Navy divers participated in three separate 7-hour exposures. Each test involved a 4-hour exposure in 37.8 C air (100 F at the surface, followed by a 3-hour immersion in 34.4 C (94 F) water at a depth of 20 fsw (1.6 ATA). The first two immersed exposures were conducted while breathing 100% oxygen at depth; once after ingesting pyridostigmine bromide (one 30 mg tablet every 8 h for two days prior to testing), and once after ingesting placebo in the same pattern. The third exposure was conducted with no drug and while breathing air at depth. The subjects performed leg exercise on a cycle ergometer in a semi-recumbent position during the immersion phase.