Early Detection Of Breast Cancer using Post-Translationally Modified Biomarkers.

摘要

In this project, we focus on oxidation and glycosylation PTMs on proteins known to be secreted by the breast as candidate biomarkers for the early detection of breast cancer. ELISA microarray technology is employed to evaluate assays that have potential be used as breast cancer biomarkers. During the second year of this project we have continued the validation for our PTM- ELISA microarray. Overall, our data suggest that the PTM ELISA microarray platform is a promising tool for discovery and evaluation of biomarkers that have potential for the early detection of breast cancer. Besides the post- translational modification, we also investigated post-transcription factors (microRNAs) for breast cancer studies. Our studies suggested that microRNAs may be a potential promising biomarkers for breast cancer.