Effect of Dosing Vehicles on the Pharmacokinetics of Orally Administered CarbonTetrachloride in Rats

摘要

The primary objectives of this investigation were to determine whether oil andaqueous dosage vehicles alter the pharmacokinetics of orally administered carbon tetrachloride (CCI4) in rats, and to relate vehicle effects on CCI4 absorption and bioavailability to alterations of the acute hepatotoxicity of CCI4 seen in a