LP1845 Liquid Gun Propellant Dermal Toxicity Studies: Evaluation of the Potentialof LP1846 Liquid Gun Propellant to Induce Unscheduled DNA Synthesis in the in vitro Hepatocyte DNA Repair Assay

摘要

The contractor assessed the ability of the test material, LP 1846 Liquid GunPropellant (LP1846), to induce unscheduled DNA synthesis (UDS) in primary cultures of male Fischer-344 (F-344) rat hepatocytes. Compound LP1846 was tested at concentrations of 0.5, 1, 5, 10, 50, 100, 250, 500,1000, 2500, and 5000 ug/ml. No increase in UDS above that of the media control level was observed after treatment of the hepatocytes with compound LP1846. Therefore, on the basis of our criterion for a positive response, LP1846 was negative in the in vitro rat hepatocyte DNA repair assay. Keywords: Liquid gun propellants; UDS; In vitro analysis; Rat hepatocytes; Genotoxicity; DNA repair; Bioassay; Liver. (EDC)