Treatment Planning for Photodynamic Therapy: Semiempirical Model and ClinicalTrials on Head and Neck Carcinoma

摘要

An optical dosimetry model for photodynamic therapy (PDT) is based on theassumption that the tumor-localized photosensitizer must absorb an energy density threshold for tumor necrosis. The relationship between delivered dose and absorbed energy was calculated for Idealized geometries with the photon diffusion equation and calibrated by scaling to PDT results for superficial tumors. The predictions of the model are compared with clinical trials on head and neck malignancies.