Interleukin-1 Induces Interleukin-6 Production in Peripheral Blood Monocytes

摘要

Multiplicity of targets and multiplicity of biologic effects are common featuresamong cytokines. Interleukin 6 (IL-6), one of the most pleiotropic and promiscuous of cytokines, has been reported to regulate the synthesis of many acute phase plasma proteins in liver cells, to promote growth and immunoglobulin (Ig) secretion in B cells infected with Epstein Barr virus (EBV), and to act as an accessory signal for mitogen costimulated T cells. IL-6 has also been reported to have antiviral activity to support colony formation by hematopoietic progenitor cells, to act as a growth factor for certain mouse B cell hybridomas and plasmacytomas, to serve as a differentiation factor for the development of cytolytic T cells, to synergize with IL-1 in the stimulation of thymocyte proliferation, and to serve as a growth factor for human plasmacytomas. Many of the biologic activities attributed to IL-6 have also been attributed to other cytokines, to hematopoietic colony stimulating factors, to interferons, and to tumor necrosis factor (TNF). In particular, IL-1 displays a number of the biologic activities of IL-6, such as regulation of growth and differentiation of cells in the immune and hematopoietic systems, and modulation of acute phase responses.