Oral Ofloxacin Therapy of Pseudomonas aeruginosa Sepsis in Mice after Irradiation

摘要

Death subsequent to whole-body irradiation is associated with gram-negativebacterial sepsis. The effect of oral therapy with the new quinolone ofloxacin for orally acquired Pseudomonas aeruginosa infection was tested in B6D2F1 mice exposed to 7.0 Gy of bilateral radiation from Co. A dose of 10 to the 7th power organisms was given orally 2 days after irradiation, and therapy was started 1 day later. Only 4 of 20 untreated mice (20%) survived for at least 30 days compared wit 19 of 20 mice (95%) treated with ofloxacin. Ofloxacin reduced colonization of the ileum by P. aeruginosa; 24 of 28 untreated mice (86%) harbored the organisms, compared with only 5 of 30 (17%) wit ofloxacin. This experiment was replicated twice, and similar results were obtained. These data illustrate the efficacy of the quinolone ofloxacin for oral therapy of orally acquired P. aeruginosa infection in irradiated hosts.