Glucose-6-Phosphate Dehydrogenase Deficiency and Hemoglobinopathies in Residentsof Arso PIR, Irian Jaya

摘要

A population of 223 persons (Javanese Irianese) was studied for glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and hemoglobinopathies. 6 Irianese were found to be G-6-PD deficient. G-6-PD levels in these individuals ranged from 4-50% of minimum normal values. 5 cases of hemoglobinopathy were detected. 1 Irianese had a hemoglobinopathy consistent with hemoglobin-Lepore Hollandia. 3 Javanese subjects expressed a variant hemoglobin consistent in electrophoretic mobility with hemoglobin E and 1 Javanese subjects expressed a variant consistent with fetal hemoglobin. While these findings demonstrate the resistance in the study population of hematologic variants that may affect susceptibility to malaria, the percent of subjects with variants probably is not great enough to significantly affect the rate of malaria transmission within the population.