ESR Study of Electron Transfer Reactions between gamma-Irradiated Pyrimidines,Adriamycin and Oxygen

摘要

The direct effect of ionizing radiation on DNA generates mainly guanine andthymine radicals. These radicals have been observed in solid DNA samples using electron spin resonance (ESR) spectroscopy. However, the exact fate of the guanine and thymine radicals when DNA is in solution is still unclear. One possibility of interest to this work, is the reaction of these radicals with other molecules in the solution generating products which may be harmful to cells. For this reason and as a model, the reaction between Gamma-irradiated pyrimidine bases with adriamycin was studied.