Studies of the Amplification of Carbaryl Toxicity by Various Oximes

摘要

The administration of 2-pyridine aldoxime methyl chloride (2-PAM C1) is astandard part of the regimen for treatment of human overexposure to many organophosphorus pesticides and nerve agents. However, some literature references indicate that poisoning by carbaryl (1-naphthyl N-methyl carbamate), an insecticide in everyday use, is aggravated by the administration of 2-PAM C1. This effect has been reported in the mouse, rat, dog, and man. We have found serum cholinesterase (Human BuChE, EC 3.1.1.8) by carbaryl was enhanced by several oximes.