Behavioral Effects of Radioprotective Agents in Mice: Combination of WR-2721 and16,16 Dimethyl Prostaglandin E2

摘要

Although the radioprotective properties of a number of compounds have beeninvestigated in the last 40 years the consideration and testing of the behavioral effects of these agents has only recently begun to be systematically investigated. Behavioral toxicity of an agent ha enhances radiotherapeutic efficacy is not necessarily a limiting factor in clinical use where small numbers of patients can be monitored and treated. However, an effective drug-screening program for radio protective agents must evaluate the behavioral toxicity of those compounds that have potential use for humans in radiation accidents and in civil defense situations.