Effect of Drugs on the Lethality in Mice of the Venoms and Neurotoxins fromSundry Snakes

摘要

Effect of several drugs on the lethality in mice of venoms and neurotoxins fromsundry snakes, Toxicon, 19. I investigated efficacy of ten drugs with respect to reducing the lethality in mice of some or all of the following venoms and their respective neurotoxins: Bungarus caeruleus venom, Bungarus multicinctus venom and alpha beta-ungarotoxin and Beta-bungarotoxin, Crotalus durissus terrificus venom and crotoxin, Notechis scutatus scutatus venom, and Oxyuranus scutellatus venom and taipoxin. Venom or toxin was administered i.p., followed immediately by an i.p. injection of drug. The effect of the drug on the lethality of the venom or toxin was recorded 24 hr later. Diltiazem, nicergoline, primaquine, verapamil, and vesamicol protected mice from the lethality of B. caeruleus venom, B. multicinctus venom, and/or Beta-bungarotoxin. Dexamethasone provided protection from B. multicinctus venom, Beta-bungarotoxin, crotoxin, O. scutellatus venom, and taipoxin. Protective activity best correlated with the charge of the drug at physiological pH. Protection from lethality was maximal when the drugs were administered immediately after the injection of venom or toxin. Nifedipine, piracetam, reserpine, and vesamicol analog 72 provided no protection from any of the venoms/toxins tested. (js)