New Electrorelease Systems Based on Microporous Membranes

摘要

Electrorelease systems have previously been based on electrochemical release ofmolecules chemically entrapped in polymer membranes. A new type of electrorelease system is described; this system is based on a microporous Al sub 2 0 sub 3 membrane covered with a barrier layer which seals the pores. Electrorelease occurs upon electrochemical dissolution or disruption of the barrier layer, which opens the pores. Two different barrier layers are investigated: silver and Na(+)-form Nafion. The electrorelease rate can be controlled by partially removing the barrier layer or by dividing the barrier layer into several individually-addressable zones. This configuration may also be used as a multi-dose device. Keywords: Drug release, Insulin release. (KR)