Alterations in Rat Cardiac Myosin Isozymes Induced by Whole-Body Irradiation are Prevented by 3,5,3'-L-Triiodothyronine.

摘要

Three types of cardiac myosin isozymes have been shown to exist within the ventricle of the heart: V1, V2, and V3. V1 contains two alpha-heavy chains, whereas V3 consist of two beta chains. V2, which is a minor component, is a heterodimer composed of one alpha- and one beta-heavy chain. The relative proportions of the cardiac myosin isozymes change under various conditions. There is a shift toward V3 isozyme with an increase in age as well as cardiac hypertrophy induced by pressure overload. (jes)