Characterization of Ligand(s) Responsible for Negative Selection of V Beta11- and V Beta12-Expressing T Cells: Effects of a New Mls Determinant.

摘要

The process of T cell development results in the maturation of a heterogenous T cell population capable of recognizing foreign antigens in association with self MHC gene products. Selective events also occur during thymic education that result in the deletion of potentially autoreactive T cells expressing TCR with high affinity for self determinants alone. The self ligands involved in the negative selection of self-reactive T cells appear to involve both MCH-and non-MCH-encoded antigens. For example, non-MHC-encoded minor lymphocyte stimulatory (Mls) antigens in association with appropriate MHC products are capable of eliciting deletion of essentially all T cells expressing certain Vbeta products, regardless of the other TCR chain products expressed. Mls and Mls have been defined as alloantigens capable of inducing strong proliferative responses by MHC-identical T cells. Keywords: Medicine. (js)