Antiviral Efficacy of Imexon in the Rauscher Murine Retrovirus AIDS Model

摘要

The murine retroviral models provide in vivo systems with which agents may betested for their capacity to suppress viremia and retroviral induced disease. The erythrotropic Rauscher murine leukemia virus (RMLV) has been used successfully for the in vivo assessment of antiviral agents and more recently treatment with the anti-Human Immunodeficiency Virus (anti-HIV) drug 3'-azido-3' deoxythymidine (AZT) reduced virus propagation leading to a longer survival period. Other drugs have also been shown to be effective in this model system. Of the agents capable of suppressing RML virus, were inhibitors of the viral reverse transcriptase (RT). In contrast, the antiviral agent castanospermine acts via a unique mechanism namely via inducing structural and functional alterations in the retroviral glycoprotein envelope.