Novel Synthetic Route to 2-Halo-3, 4-Dicyanopyridines.

摘要

Two-Bromo-3,4-dicyanopyridine 2 was obtained in moderate yield by reacting 1,1,2,2-tetracyano-3-trimethylsiloxycyclobutane 1 with phosphorus tribromide. Similarly, reaction of 1 with chlorinating reagents such as thionyl chloride and oxalyl chloride led to the corresponding 2-chloro-3, 4-dicyanopyridine 3 in 40% yield. A reaction mechanism is suggested. (AW)