Quantitation of Cellular Kinetics for the Modelling of Chemically-Induced Carcinogenesis.

摘要

The Air Force Installation Restoration Program (IRP) is involved in assessing and managing health risks from exposure to toxic chemical contamination at hazardous waste sites on Air Force facilities. In human health risk assessment, data from epidemiological studies are valuable when available. However, data from animal studies are usually extrapolated to humans because the human data are often insufficient. Thus, uncertainties arise concerning the relevance of the animal data to humans. This report presents the results of an independent evaluation of selected relevant scientific literature. It identifies and discusses experimental methods that are potentially useful for the quantitation of parameters that are necessary for the modeling of chemically-induced cellular changes that occur in carcinogenesis. The report presents an overview of the cell dynamics of carcinogenesis in terms of a conceptual two-stage model and briefly evaluates experimental approaches which may be applicable, focusing especially on the liver and lung of rodents.