Equipment Support Grant for Air Force Task 'Chemical Defense Drugs Effects with Exercise and Thermal Stress'.

摘要

The effects of a single intramuscular atropine injection (0.03 mg/kg ) at ambient temperatures (Ta) of 25 C and 35 C and pyridostigmine treatment (5 doses (0.4 mg/kg)) at Ta of 35 C on the thermoregulatory capacity and exercise tolerance time of patas monkeys were investigated. A primate treadmill device was developed and used to evaluate the effects of the drugs on the exercise tolerance time. Rectal temperature (Tre) and heart rate (HR) were continuously monitored by a telemetry system while water loss was estimated from weight differences before and after exercise. Atropine effects were more pronounced at Ta of 35 C as indicated by a significant reduction in water loss (43%) which was associated with an average exercise time of 65 min less than the control value. The final HR and Tre responses in these atropine experiments were significantly elevated above the control values. Pyridostigmine significantly increased water loss (61%) which was associated with an average exercise time of 60 min longer than the control value. (js)