Structure and Design of Multipotent Peptide Microbicides.

摘要

Defensin peptides, naturally occurring neutrophil antibiotics, were purified and characterized functionally and structurally. Functional differences in microbicidal potency and spectrum were correlated with structural features resolved by NMR and crystallographic methods. Protocols were established for synthesis and disulfide formation of natural defensins and synthetic congeners; we are currently investigating the latter by structural and functional characterization. Peptides, Structure-activity relationships, Synthesis, Microbicides, Antimicrobial peptides. (kt)