Comparison of Pyrimidinone Analogue Immunomodulators for Treatment of PhlebovirusInfections in Mice

摘要

The Punta Toro virus (PTV), Phlebovirus in the Bunyaviridae, has recently beenshown to be useful as a model for the severe human pathogen, Rift Valley fever virus. It has especially been used in the study of chemotherapeutic agents which may be considered for use in treating this potentially lethal disease. The PTV-induced infection in mice is characterized by fulminant hepatocellular necrosis leading to death of the animal. This hepatotropism by PTV has been evidenced by development of severely discolored and mottled livers, extensive hepatic lesions seen by histopathology, and accumulation of high titres of virus in the liver. Later studies also showed that serum glutamic oxalic acid and pyruvic acid transaminases developed in direct correlation to liver discoloration.