Antineoplastic Agents. 168. Isolation and Structure of Axinohydantoin

摘要

Early in our evaluation of marine animals as new sources of potentially usefulanticancer drugs, good leads were uncovered among the Porifera, and this initial (1966-1968) promise is now being amply realized. In 1979 in Palau we collected a Hymeniacidon species (at -40 m) and an Axinella sp. that provided extracts with confirmed levels of activity against the U.S. National Cancer Institute's (NCI) murine P388 lymphocytic leukemia (PS system). Initial extracts of each sponge were found to provide a confirmed level of activity against the PS system. By means of PS (in vitro) bioassay guided separation procedures, these sponge species led to two cytostatic and antineoplastic alkaloids accompanied in the case of Axinella sp. by a closely related, but marginally inactive, component. The PS active marine alkaloids proved to be identical with the known hymenialdisine.