Studies of Cobalamin as a Vehicle for the Renal Excretion of Cyanide Anion

摘要

To examine the ability of hydroxocobalamin (vitamin B 12a, HO-Cbl) to counteractthe toxicity of cyanide by promoting the renal excretion of cyanide anion, we studied the pharmacokinetics of HO-C61 and cyanocobalamin (vitamin B12 CN-Cbl) given in high doses to dogs. After administration of intravenous bolus doses of HO-Cbl and CN-Cbl (5, 10, 25 mg/kg) to female foxhounds, peak plasma concentrations were attained within 1 minute, after which the cobalamins disappeared from plasma in a manner consistent with two-phase distribution and elimination kinetics.