Evaluation of an In vitro Assay Aimed at Measuring Protective Antibodies againstSporozoites

摘要

The feasibility of successfully developing a vaccine against sporozoite challengehas rested largely on successes in protecting mice and some humans with irradiated sporozoites. Several studies have indicated that antibodies (5), CD8+ T cells, and cytokines released by immuno-competent cells can interfere with the pre-erythrocytic phase of parasite development. However, information from malaria animal models have demonstrated that antibodies alone, either monoclonal (MAb) or polyclonal, can be fully or partially effective in preventing infection in sporozoite challenged animals.