Development of Methods for Carrier-Mediated Targeted Delivery of AntiviralCompounds Using Monoclonal Antibodies (Final Report)

摘要

SRI International and Utah State University developed methodology to assess theeffectiveness of antiviral drug monoclonal antibody conjugate therapy for the treatment of viral infections. Specifically, monoclonal antibodies to Pichinde virus surface antigens were prepared and conjugated to the antiviral drug ribavirin, and the resulting conjugates were screened for antiviral activity in vitro. Immunoconjugates were inactive because the monoclonal antibody did not internalize. Subsequent work using a polyclonal antibody produced an immunotoxin that had antiviral activity. Animal model systems were developed for in vivo evaluations. (js)