Immune Response to Plasmodium Berghei Sporozoite Antigens. I. Evaluation ofMurine T Cell Receptors Following Immunization with Irradiated Sporozoites

摘要

Information regarding T cell responses to complex antigens found on parasites,like the protozoan Plasmodia, is incomplete and fragmentary. Throughout this study, we were guided by the lessons learned from extensively studied immune responses to soluble protein antigens. The usefulness of this approach should be critically evaluated so that studies dealing with immune reactiveness elicited by antigenically complex parasites could either assume new directions or continue to rely on the models provided by the well characterized protein antigen systems.